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Literature summary extracted from

  • Packiam, M.; Yedery, R.D.; Begum, A.A.; Carlson, R.W.; Ganguly, J.; Sempowski, G.D.; Ventevogel, M.S.; Shafer, W.M.; Jerse, A.E.
    Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection (2014), Infect. Immun., 82, 2170-2179.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.43 additional information construction of a leptA knockout mtant Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae FA 1090
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.43 Neisseria gonorrhoeae
-
 gene lptA
-
2.7.8.43 Neisseria gonorrhoeae FA 1090
-
 gene lptA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Neisseria gonorrhoeae diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Neisseria gonorrhoeae FA 1090 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.43 PEA transferase A
-
 Neisseria gonorrhoeae

General Information

EC Number General Information Comment Organism
2.7.8.43 malfunction wild-type Neisseria gonorrhoeae strain FA1090 has a survival advantage relative to a PEA transferase A (lptA) mutant in the human urethral-challenge and murine lower genital tract infection models. Purified lipooligosaccharide containing lipid A devoid of the phosphoethanolamine modification and an lptA mutant of strain FA19 induce significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type lipooligosaccharide of the parent strain. Vaginal proinflammatory cytokines and chemokines are not elevated in female mice infected with the isogenic lptA mutant, in contrast to mice infected with the wild-type and complemented lptA mutant bacteria. lptA mutant bacteria are more susceptible to human and murine cathelicidins due to increased binding by these peptides and that the differential induction of NF-kappaB by wild-type and unmodified lipid A is more pronounced in the presence of cationic antimicrobial peptides. Wild-type but not lptA mutant gonococci induce a proinflammatory response during infection Neisseria gonorrhoeae
2.7.8.43 physiological function wild-type Neisseria gonorrhoeae strain FA1090 has a survival advantage relative to a PEA transferase A (lptA) mutant in the human urethral-challenge and murine lower genital tract infection models. Wild-type lipid A stimulates the humanTLR4-MD2-CD14 complex Neisseria gonorrhoeae